ArticleBMC cardiovascular disorders2026
Trends in cardiovascular mortality (1999-2023) in the United States: an analysis of underlying causes of death using the CDC WONDER database.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesNational statistics on mortality due to cardiovascular disease (CVD) in the United States remain insufficiently characterized. This study aimed to analyze the long-term trends and subgroup disparities in CVD-related mortality across the US from 1999 to 2023.
methodsWe utilized the CDC WONDER database to identify all US residents with CVD recorded as the only underlying cause of death from 1999 to 2023 (ICD-10 codes: I00-I99). Age-adjusted mortality rates (AAMRs) per 100,000 population and average annual percent changes (AAPCs) with 95% confidence intervals (CIs) were calculated via Joinpoint regression analysis (version 5.3.0).
resultsIn the United States, the number of cardiovascular-related deaths decreased from 954,339 in 1999 to 915,973 in 2023. Concurrently, the overall AAMR fell from 350.76 (95% CI: 350.06 to 351.47) in 1999 to 218.32 (95% CI: 217.87 to 218.77) in 2023, reflecting an AAPC of -1.95 (95% CI: -2.36 to -1.55). Notably, AAMR was consistently higher in men compared to women (2023: 263.04 vs. 180.16). An analysis by race indicated that non-Hispanic blacks experienced the highest mortality in 2023 (290.03 (95% CI: 288.35 to 291.72)), followed by whites (223.73 (95% CI: 223.19 to 224.27)), Hispanics (156.65 (95% CI: 155.42 to 157.88)), and individuals from other racial backgrounds (124.21 (95% CI: 122.92 to 125.49)). Regionally, the South exhibited the highest AAMR in 2023 (234.53 (95% CI: 233.77 to 235.30)), succeeded by the Midwest (231.41 (95% CI: 230.39 to 232.42)), the West (197.25 (95% CI: 196.35 to 198.16)), and the Northeast (194.97 (95% CI: 193.99 to 195.96)). Furthermore, the AAMR was most pronounced among individuals aged over 85 years. Between 1999 and 2020, AAMR was notably higher in rural regions compared to urban areas, with a widening gap after 2011.
conclusionThe age-adjusted mortality rate of CVD in the United States continued to decrease from 1999 to 2023, with the highest burden among men, non-Hispanic black, rural areas, and individuals over 85 years of age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.