ArticleEuropean journal of neurology2026
Clinical Efficacy of Revascularization Surgery for Moyamoya Angiopathy: Long-Term Results of a European Cohort.
Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical Efficacy of Revascularization Surgery for Moyamoya Angiopathy: Long-Term Results of a European Cohort.European journal of neurology · 2026Article
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11 authors.
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Abstract
backgroundMoyamoya angiopathy (MMA) is a cerebrovascular disease treated by surgical revascularization. This study aimed to present long-term outcomes of European MMA patients after surgical revascularization.
methodsMMA patients treated surgically between 1998 to 2023 were included. Follow-up comprised clinical and radiological examinations and electronic questionnaires. Patient data were analyzed retrospectively, and logistic regressions were performed to identify predictors of unfavorable outcomes.
resultsA total of 276 patients with 428 surgically treated hemispheres were included. The mean age was 35.0 ± 17.2 years, including 192 women and 84 men, predominantly of Caucasian ethnicity (88.0%). Ischemia (82.2%) and hemorrhage (10.1%) were the most common symptoms at onset. Most adults (80.9%) were treated with combined bypass surgery via mini-craniotomy. Within 30 days, complications occurred in 6.3% of surgeries, and the perioperative stroke risk was 2.6%. A total of 148 patients underwent in-house follow-up. No mRS scores ≥ 5 were observed, with 86.3% of patients achieving a score of 0-2, alongside a bypass patency rate of 95.7% and a stroke risk of 0.3% per patient-year. Preoperative stroke and silent ischemic MRI lesions were identified as predictors of an unfavorable outcome. Additionally, 201 patients were followed up electronically. No mRS scores ≥ 5 were observed, with 87.9% of patients achieving a score of 0-2. Moreover, 90.7% were independent in daily life, but only 50.5% returned to work or school.
conclusionsCombined bypass surgery yielded favorable outcomes with low complication and stroke rates. Patients with preoperative stroke require closer follow-up, and individualized strategies are needed to address persistent functional impairments.
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