ArticleScientific reports2026
Long-term outcomes after endoscopic resection of gastric adenocarcinoma of the fundic gland type and oxyntic gland adenoma: a retrospective cohort study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastric adenocarcinoma of the fundic gland type (GA-FG) and oxyntic gland adenoma (OGA) are recently recognized neoplasms arising from the oxyntic mucosa; however, their long-term clinical behavior after endoscopic treatment remains poorly defined. Here, we present one of the largest multicenter cohorts with extended follow-up to clarify their long-term outcomes. We retrospectively analyzed 72 patients who underwent endoscopic resection, with a mean clinical follow-up of 68 months. No disease-specific deaths were observed during follow-up. Among 66 patients with adequate endoscopic follow-up, the mean endoscopic follow-up period was 65 months. Remarkably, no local recurrence was observed, confirming durable local control after resection. Despite this excellent prognosis, metachronous lesions developed in 3 patients (4.5%) at distinct gastric sites, all of which were successfully treated endoscopically. These findings demonstrate that GA-FG/OGA exhibit indolent behavior with outstanding long-term outcomes following endoscopic resection. However, the occurrence of metachronous tumors suggests a field cancerization-like process in the oxyntic mucosa, underscoring the need for long-term surveillance.
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