Evidence map›Paper›PMID 42286233›Full record

ArticleBritish journal of cancer2026

Adjuvant radiotherapy and skin cancer risk in breast cancer survivors: a nationwide cohort study in Korea.

Je Hyun Chin, Dooreh Kim, Hye Sun Lee, Soyoung Jeon, Jin Ah Lee, Young Joo Lee, Soo Youn Bae, Woo-Chan Park, Jin Ho Song, Chang Ik Yoon

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Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Je Hyun Chin *Division of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Dooreh Kim *Division of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hye Sun LeeBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.
Soyoung JeonBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-9916-1917
Jin Ah LeeDivision of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Young Joo LeeDivision of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID http://orcid.org/0000-0001-5352-8093
Soo Youn BaeDivision of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Woo-Chan ParkDivision of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jin Ho SongDepartment of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Chang Ik YoonDivision of Breast Surgery, Department of Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. fayn03@catholic.ac.kr.ORCID http://orcid.org/0000-0002-7273-8886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdjuvant radiotherapy (RT) is standard for breast cancer, but its impact on skin cancer risk, especially in Asian populations, remains unclear despite advanced techniques. This study aimed to assess skin cancer incidence following RT in a large South Korean cohort.

methodsThis retrospective cohort study, using South Korean Health Insurance Review and Assessment Service data (2009-2012), included 37,957 patients aged ≥20 with invasive breast cancer or ductal carcinoma in situ who underwent curative surgery. Prior malignancies or oncological treatment were excluded. Incidence of malignant melanoma and non-melanoma skin cancers were assessed. 1:1 propensity score matching was performed to balance confounders, resulting in 19,856 matched patients (9928 per group). Multivariable Cox proportional hazards models identified risk factors.

resultsPost-matching, skin cancer incidence was comparable between RT and non-RT (NRT) groups (0.97% vs. 1.02%; p = 0.720). RT showed no significant association with overall skin cancer (p = 0.604), malignant melanoma (p = 0.094) or non-melanoma skin cancer (p = 0.196). Increased risk was associated with older age, mole presence (HR 5.254), pre-malignant skin lesions (HR 12.905), and lymphedema (HR 1.978).

conclusionAdjuvant RT did not increase skin cancer risk after breast cancer surgery. Dermatologic factors and lymphedema were principal predictors, emphasising vigilant follow-up in at-risk patients.

Indexed as

Breast NeoplasmsNeoplasms, Radiation-InducedSkin NeoplasmsAdultAgedCancer SurvivorsCohort StudiesFemaleHumansIncidenceMelanomaMiddle AgedNon-Melanoma Skin NeoplasmsRadiotherapy, AdjuvantRepublic of KoreaRetrospective Studies

Identifiers

PMID42286233
PMCPMC13478469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.