Evidence map›Paper›PMID 42286210›Full record

ArticleAngiogenesis2026

Endothelial AGO1 deficiency reduces breast cancer burden in mice.

Xuejing Liu, Alonso Tapia, Dongqiang Yuan, Xiaofang Tang, Yingjun Luo, Naseeb Kaur Malhi, Muxi Chen, Kwan Ho Law, Mohamad Haidar, Skylar Giacobetti and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xuejing Liu *Department of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Alonso Tapia *Department of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Dongqiang YuanDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Xiaofang TangDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Yingjun LuoDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Naseeb Kaur MalhiDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Muxi ChenDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Kwan Ho LawDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Mohamad HaidarDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Skylar GiacobettiDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Jiawei SunDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Anthony ParkDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
Saul J PricemanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
Zhen Bouman ChenDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, USA. zhenchen@coh.org.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
RNA-mediated endotheliopathy in diabetic vasculopathyR35HL171550 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zhen Bouman Chen · 2024 to 2026
$2.2M
National Cancer Institute of the NIH P30CA033572NIH HHS R01143577NIH HHS R35HL171550
6 · The paper itself

Abstract

Endothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and immune modulation. As a key component of the RNA-induced silencing complex, Argonaute 1 (AGO1) regulates tumor biology, yet the specific function of AGO1 within ECs in the tumor microenvironment remains undefined. Here, we investigated the effects of endothelial-specific AGO1 knockout (EC-AGO1-KO) on tumor vascularization and immune regulation in a mouse syngeneic breast cancer model induced by E0771 cells. EC-AGO1-KO mice exhibited significantly reduced tumor burden compared to their wild-type (WT) littermates, accompanied by reduced vascularization and enhanced immune cell infiltration. Histological and single-cell RNA sequencing analyses revealed increased infiltration of CD8⁺ T cells and macrophages in EC-AGO1-KO tumors, indicative of an immunostimulatory microenvironment. In vitro, AGO1 knockdown in mouse ECs co-cultured with E0771 tumor cells led to higher levels of Cxcl10 and Vcam1 expression, suggesting a pro-inflammatory and leukocyte-recruiting effect. Together, these findings identify endothelial AGO1 as a key regulator of tumor vasculature and immune homeostasis in breast cancer, suggesting that targeting endothelial AGO1 may represent a novel therapeutic strategy to modulate tumor vasculature while enhancing anti-tumor immunity.

Indexed as

Argonaute ProteinsEndothelial CellsEukaryotic Initiation FactorsMammary Neoplasms, ExperimentalNeovascularization, PathologicTumor BurdenAnimalsCD8-Positive T-LymphocytesCell Line, TumorChemokine CXCL10FemaleMiceMice, KnockoutTumor MicroenvironmentArgonaute ProteinsChemokine CXCL10Eukaryotic Initiation FactorsArgonaute 1 (AGO1)Breast cancerEndothelial cells (ECs)Tumor immunology

Identifiers

PMID42286210
PMCPMC13263250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.