Trial reportScientific reports2026
High-intensity interval training differentially modulates acute BDNF and cognitive responses in young adult males: a randomized crossover trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07137611 (Effect of Exercise Intensity on Neurochemical and Cognitive Function), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise Intensity on Neurochemical and Cognitive Function: The Role of Lactate and BDNF
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise is widely recognized for its beneficial effects on brain health, yet the extent to which exercise intensity modulates acute neurochemical and cognitive responses remains unclear. Particularly, the role of exercise intensity in shaping brain-derived neurotrophic factor (BDNF), lactate responses, and executive function requires further investigation. This study compared the acute effects of low-intensity continuous training (LICT), moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and a resting control condition (CTRL) on BDNF levels, blood lactate concentration, and cognitive responses in healthy young adult males. Twelve healthy young adult males completed LICT, MICT, HIIT, and the control condition using a randomized crossover design with a 7-day washout period. Serum BDNF, blood lactate concentration, and executive function assessed by the Stroop Test were measured before and immediately after each experimental condition. HIIT induced significantly greater post-exercise increases in BDNF and lactate compared with all other conditions, while MICT elicited moderate elevations relative to LICT and rest. Lactate responses increased progressively with exercise intensity. Improvements in executive function were observed exclusively following HIIT, reflected by significantly faster Stroop Test completion times. HIIT produced concurrent elevations in lactate and serum BDNF together with improved executive function performance. HIIT may represent an effective acute stimulus for cognitive benefits, with potential relevance for exercise approaches aimed at supporting brain health via neurotrophic signaling.Trial registration: The study was retrospectively registered on ClinicalTrials.gov (identifier: NCT07137611; https://clinicaltrials.gov/study/NCT07137611 ) on 22 August 2025.
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