Evidence map›Paper›PMID 42286129›Full record

ArticleScientific reports2026

Detection of recurrence of HPV-driven oropharyngeal cancer by HPV cell-free DNA.

Noemi M Fricke, Vittoria Guarda, Daniela Höfler, Tim Waterboer, Charlotte S Schouten, Kristian Ikenberg, Lea Schroeder, Fabian Rosing, Martina A Broglie Daeppen

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Noemi M Fricke *Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. noemi.fricke@dkfz-heidelberg.de.
Vittoria Guarda *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland.
Daniela HöflerDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tim WaterboerDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Charlotte S SchoutenDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland.
Kristian IkenbergDepartment of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.
Lea SchroederDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fabian Rosing *Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Martina A Broglie Daeppen *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of oropharyngeal cancer (OPC) driven by human papillomavirus (HPV) is increasing in high-income countries. Recurrent tumors remain a major cause of HPV-OPC mortality, yet reliable biomarkers for post-treatment monitoring are lacking. This study evaluated HPV cell-free DNA (cfDNA) from blood plasma as a monitoring biomarker for the detection of HPV-OPC recurrence. Blood plasma from 59 OPC patients was collected at diagnosis and during follow-up. HPV cfDNA was quantified using a multiplex digital PCR assay targeting HPV16 and seven other high-risk types. Tumor HPV status was confirmed by p16

Indexed as

Cell-Free Nucleic AcidsDNA, ViralHuman Papillomavirus VirusesNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedBiomarkers, TumorCell-Free Nucleic AcidsDNA, Viral

Identifiers

PMID42286129
PMCPMC13263334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.