Evidence map›Paper›PMID 42286022›Full record

ArticleNature communications2026

Nitrate-Sialin2 axis couples ER-mitochondrial calcium signaling with fatty acid metabolism to drive white adipose browning.

Ou Jiang, Zichen Cao, Sihan Kong, Qibing Wu, Tianyi Zhang, Xinyue Chen, Bo Zhou, Yao Feng, Songyue Wu, Jinsong Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ou Jiang *Laboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Zichen Cao *Laboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Sihan KongLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Qibing WuLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Tianyi ZhangLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Xinyue ChenLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Bo ZhouLaboratory of Oral Homeostatic Medicine, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0003-4213-726X
Yao FengLaboratory of Oral Homeostatic Medicine, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen, China.
Songyue WuLaboratory of Oral Homeostatic Medicine, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0004-6565-9110
Jinsong WangLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Mo ChenLaboratory of Oral Homeostatic Medicine, School of Medicine and SUSTech Homeostatic Medicine Institute (SHMI), Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-3274-5889
Xiaoyu LiLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China. xiaoyu9449@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-8177-1813
Songlin WangLaboratory of Oral Health and Homeostatic Medicine, Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China. slwang@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-7066-2654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White adipose browning is a promising route to restore energy balance; however, how inorganic anion signals engage intracellular organelle networks to drive this process remains unclear. Here, we identify Sialin2 as a nitrate sensor that converts dietary nitrate into a spatially confined thermogenic program by coupling ER-mitochondria Ca

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteCalcium SignalingEndoplasmic ReticulumFatty AcidsMitochondriaNitratesAnimalsCalciumHumansMaleMiceMice, Inbred C57BLThermogenesisCalciumFatty AcidsNitrates

Identifiers

PMID42286022
PMCPMC13408447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.