Evidence map›Paper›PMID 42286021›Full record

ArticleScientific reports2026

Endoglin (CD105) overexpression is associated with an immunosuppressive tumor microenvironment in murine lung cancer models and human lung adenocarcinoma.

Claudia Ollauri-Ibáñez, Blanca Ayuso-Íñigo, Inés Solano-Sc, Paula Díez, Martín Perez-Andres, José M Muñoz-Félix, Alicia Rodríguez-Barbero, Miguel Pericacho

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia Ollauri-Ibáñez *Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Blanca Ayuso-Íñigo *Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Inés Solano-ScInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Paula DíezInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Martín Perez-AndresInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
José M Muñoz-FélixInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Alicia Rodríguez-BarberoInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain.
Miguel PericachoInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, 37007, Spain. pericacho@usal.es.

Funding

Instituto de Salud Carlos III PI16/00460Instituto de Salud Carlos III,Spain PI19/01630Junta de Castilla y León BIO/SA83/13Ministerio de Economía y Competitividad of Spain PID2022-138765OB-I00
6 · The paper itself

Abstract

The tumor microenvironment (TME) is a major determinant of tumor response to different therapies, especially immunotherapy. Tumors with high CD8

Indexed as

AdenocarcinomaAdenocarcinoma of LungEndoglinLung NeoplasmsTumor MicroenvironmentAnimalsCarcinoma, Lewis LungCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalGene Expression Regulation, NeoplasticHumansMiceMice, Inbred C57BLMice, TransgenicEndoglinENG protein, humanAngiogenesisCold tumorEndoglin (CD105)Lung cancerTumor microenvironment (TME)

Identifiers

PMID42286021
PMCPMC13518793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.