Evidence map›Paper›PMID 42285973›Full record

ReviewNature communications2026

Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis.

Babak Borhan, Amanda M Murray, Amir Ata Saei, Bahareh Ghaffari, James E Jackson, Naseeha Mohammed, Michael J Mitchell, Hojatollah Vali, Kathryn A Whitehead, Morteza Mahmoudi

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Babak BorhanDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, USA. babak@chemistry.msu.edu.ORCID http://orcid.org/0000-0002-3193-0732
Amanda M MurrayDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0009-0000-2124-351X
Amir Ata SaeiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, 171 77, Sweden.ORCID http://orcid.org/0000-0002-2639-6328
Bahareh GhaffariDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, USA.ORCID http://orcid.org/0000-0003-0126-334X
James E JacksonDepartment of Chemistry, Michigan State University, East Lansing, MI, 48824, USA.ORCID http://orcid.org/0000-0002-4506-7415
Naseeha MohammedDepartment of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0007-6680-1133
Michael J MitchellDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-3628-2244
Hojatollah ValiDepartment of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 0C7, Canada.
Kathryn A WhiteheadDepartment of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. kawhite@andrew.cmu.edu.ORCID http://orcid.org/0000-0002-0100-7824
Morteza MahmoudiPrecision Health Program, Michigan State University, East Lansing, MI, 48823, USA. mahmou22@msu.edu.ORCID http://orcid.org/0000-0002-2575-9684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2018, ionizable lipid nanoparticles (LNPs) have revolutionized nucleic acid therapeutics. However, achieving potent extrahepatic delivery remains a formidable challenge, primarily due to rapid hepatic uptake driven by apolipoprotein adsorption. While analyzing the LNP protein corona is essential for engineering organ-specific tropism, these soft materials present unique analytical hurdles. Co-isolation of blood-borne contaminants, such as extracellular vesicles and lipoproteins, often masks the true corona composition. This perspective examines the critical need for refined proteomic strategies to distinguish genuine corona proteins from impurities. We propose tailored investigative approaches, suggesting the LNP protein corona significantly differs from the rigid shells observed on inorganic nanoparticles.

Indexed as

Extracellular VesiclesLipidsLipoproteinsNanoparticlesProtein CoronaAnimalsHumansLiposomesProteomicsLipid NanoparticlesLipidsLipoproteinsLiposomesProtein Corona

Identifiers

PMID42285973
PMCPMC13263340

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.