Direct Asymmetric α-C Conjugate Addition of Aminomethylphosphonate Enabled by Carbonyl/Iminium Double Organoactivation.

Pengwei Ji, Xingdie Yang, Weibo Ling, Songnan Zhang, Tongyin Chen, Wen-Wen Chen, Siqi Liu, Baoguo Zhao

Abstract read

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Pengwei JiThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.

Xingdie YangThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.

Weibo LingThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.

Songnan ZhangThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.

Tongyin ChenThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.

Wen-Wen ChenThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China. wenwen@shnu.edu.cn.ORCID http://orcid.org/0000-0002-2723-2843

Siqi LiuThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China. liusq@shnu.edu.cn.ORCID http://orcid.org/0000-0002-1428-9541

Baoguo ZhaoThe Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China. zhaobg2006@shnu.edu.cn.ORCID http://orcid.org/0000-0001-7579-6670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As important bioisosteres of α-amino acids, chiral α-aminophosphonic acids exhibit broad bioactivities and are widely employed in pharmaceuticals. Direct asymmetric α-C conjugate addition of aminomethylphosphonate to α,β-unsaturated ketones is an intriguing strategy to make bioactive chiral phosphonic 1-pyrrolines. However, this transformation remains challenging due to the low α-C-H acidity of the aminomethylphosphonate, significant steric hindrance from the phosphonate moiety and interference by side reactions. In this work, we report the direct enantioselective α-C conjugate addition of NH

Identifiers

PMID42285962

DOI10.1038/s41467-026-74370-9

PMCPMC13409000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.