Evidence map›Paper›PMID 42285762›Full record

ArticleeNeuro2026

A Distinct Adolescent Profile for Activity and Dopamine Release in the Nucleus Accumbens during Pavlovian Conditioning.

Ethan W Herring, Madalyn Hafenbreidel, Eesha D Patel, Sandford Zeng, Tulasi Syamala, Paul Kupelian, Mary M Torregrossa, Sara E Morrison

Abstract read
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ethan W HerringDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Madalyn HafenbreidelPsychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Eesha D PatelDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Sandford ZengDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Tulasi SyamalaDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Paul KupelianDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Mary M TorregrossaPsychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.ORCID https://orcid.org/0000-0003-2083-0231
Sara E MorrisonDepartments of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 sara.morrison@pitt.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Across species, adolescence is a time of heightened reward sensitivity and enhanced impulsivity and risk-taking. In adults, these behavioral features are linked with a tendency to approach and interact with reward-associated cues-a behavior known as sign tracking (ST)-which is thought to reflect the transfer of incentive salience from reward to cue. Counterintuitively, adolescents are less likely to exhibit ST, compared with adults, and more likely to exhibit goal tracking, or approach to the site of reward. To investigate a possible neural basis for this age difference, we recorded the activity of individual neurons in the nucleus accumbens (NAc) of male and female rats during Pavlovian conditioning in adolescence and adulthood. In a separate group, we used a fluorescent indicator (GRAB

Indexed as

AgingConditioning, ClassicalDopamineNeuronsNucleus AccumbensAge FactorsAnimalsCuesFemaleMaleRatsRewardDopamineadolescentdopaminenucleus accumbensPavlovianrewardsign tracking

Identifiers

PMID42285762
PMCPMC13313804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.