Evidence map›Paper›PMID 42285196›Full record

ArticleBiological psychiatry2026

Lower Muscarinic M

Tommaso Volpi, Rajiv Radhakrishnan, Rachel Hird, Mika Naganawa, Nabeel Nabulsi, Soheila Najafzadeh, Swanee Jacutin-Porte, David Labaree, Richard E Carson, Yiyun Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tommaso VolpiDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut. Electronic address: tommaso.volpi@yale.edu.
Rajiv RadhakrishnanDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut.
Rachel HirdDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut.
Mika NaganawaDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Nabeel NabulsiDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Soheila NajafzadehDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Swanee Jacutin-PorteDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
David LabareeDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Yiyun HuangDepartment of Radiology and Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
Deepak C D'SouzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut.

Funding

Novel PET Radiotracer for Muscarinic M1 ReceptorR01MH113557 · NIMH · YALE UNIVERSITY · PI HUANG, YIYUN HENRY · 2017 to 2019
$2.8M
Preliminary studies of muscarinic M1 receptor availability and cognition in schizophreniaR21MH123870 · NIMH · YALE UNIVERSITY · PI D'SOUZA, DEEPAK CYRIL, RADHAKRISHNAN, RAJIV · 2021 to 2022
$461k
NIMH NIH HHS R01 MH113557NIMH NIH HHS R21 MH123870
6 · The paper itself

Abstract

backgroundThere is growing interest in the contributions of brain muscarinic M

methodsM

resultsCompared with HCs, patients with SZ showed significantly lower M

conclusionsTogether with postmortem data, these in vivo findings warrant further characterization of M

Indexed as

CognitionIn vivoMuscarinicPositron emission tomographyReceptorSchizophrenia

Identifiers

PMID42285196
PMCPMC13507943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.