SynthesisJournal of optometry
"OCT based retinal changes in amblyopia: A systematic review".
Synthesis in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo synthesise evidence on retinal, choroidal, and microvascular alterations detected by OCT/OCTA in amblyopic eyes and their modulation by conventional therapy. METHODOLOGY: MEDLINE, Embase, Scopus, and Cochrane CENTRAL were searched without language restrictions, along with manual screening of reference lists and relevant trial registries. Eligible studies included cross-sectional or longitudinal human studies comparing OCT/OCTA parameters in amblyopic eyes with fellow or age-matched control eyes. Two reviewers independently performed study screening, data extraction, and quality assessment. Due to substantial clinical and methodological heterogeneity among the included studies, a qualitative narrative synthesis was conducted to summarize findings across studies. Results were stratified according to amblyopia subtype and treatment status.
resultsThirty studies were included. Most studies reported increased RNFLT and central macular thickness in anisometropic amblyopia, whereas findings in strabismic amblyopia were inconsistent. OCTA studies commonly demonstrated reduced superficial capillary plexus density in untreated amblyopic eyes. Longitudinal studies showed modest therapy-related structural changes, with possible earlier microvascular improvement. Methodological heterogeneity and incomplete axial-length correction were common limitations across studies.
conclusionsOCT/OCTA reveal consistent retinal thickening and superficial vascular reduction in anisometropic amblyopia, while other types show minimal changes. Standardized, axial length-corrected longitudinal studies are needed to clarify causality and prognostic significance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.