Pharmaceutical agents targeting K

Chika Sawai, Kuanyu Wang, Kengo Horie, Yoshihiro Mitoh, Hirotaka Ueda, Hiroshi Kamioka, Ryusuke Yoshida

Abstract read

In one paragraph

Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chika SawaiDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Kuanyu WangDepartment of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Kengo HorieDepartment of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Yoshihiro MitohDepartment of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Hirotaka UedaDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Hiroshi KamiokaDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Ryusuke YoshidaDepartment of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan. Electronic address: yoshida.ryusuke@okayama-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sweet detection involves at least two mechanisms: a G-protein coupled sweet taste receptor (Tas1r2/Tas1r3) and glucose transporters. As in pancreatic β-cells, glucose transport may lead to closure of ATP-sensitive potassium (K

Indexed as

DiazoxideGlyburideKATP ChannelsSweetening AgentsTasteAnimalsGlucoseInsulinMaleMiceMice, Inbred C57BLReceptors, G-Protein-CoupledSucroseDiazoxideGlucoseGlyburideInsulinKATP ChannelsReceptors, G-Protein-CoupledSucroseSweetening AgentsCephalic phase insulin releaseDiabetesGlucose transporterSweet taste receptorTaste disorder

Identifiers

PMID42284632

DOI10.1016/j.jphyss.2026.100082

PMCPMC13279012

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.