ArticleEnvironmental science & technology2026
Probabilistic Concentration-Response Modeling and Risk Prioritization of Defined Mixtures of PFAS Using Human
Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants. Some individual PFAS are linked to adverse health effects, but little data is available to evaluate PFAS mixtures. We tested the biological effects of 20 defined PFAS mixtures (containing 4-56 PFAS) across eight human cell types, including iPSC-derived cardiomyocytes, neurons, and hepatocytes; primary hepatocytes; and HepG2s, endothelial, and renal proximal tubule epithelial cell lines. Mixtures were designed to reflect realistic exposures based on drinking/surface water data, regulatory limits, biomonitoring results, and prior
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