ArticleJournal of bacteriology2026
Heparin-binding enhances extracellular listeriolysin O activity, overcoming cholesterol inhibition and pH dependence.
Luigi La Pietra, Helena Pillich, Martina Hudel, Besim Berisha, Mobarak Abu Mraheil, Andreas Geissner, Peter H Seeberger, Trinad Chakraborty
Abstract read
In one paragraphArticle in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Luigi La PietraInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.ORCID 0000-0003-2321-6990 Helena PillichInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.
Martina HudelInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.
Besim BerishaInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.
Mobarak Abu MraheilInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.
Andreas GeissnerBiomolecular Systems Department, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
Peter H SeebergerBiomolecular Systems Department, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.ORCID 0000-0003-3394-8466 Trinad ChakrabortyInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Giessen, Germany.ORCID 0009-0003-4875-3036 Funding
Deutsche Forschungsgemeinschaft (DFG) CRC TRR84 A04Max-Planck-Gesellschaft (MPG) CRC TRR84 C08
6 · The paper itselfAbstract
The membranolytic toxin listeriolysin O (LLO), a member of the family of bacterial cholesterol-dependent cytolysins (CDC), is a key virulence factor of
Indexed as
Bacterial ToxinsCholesterolHeat-Shock ProteinsHemolysin ProteinsHeparinListeria monocytogenesAnimalsBinding SitesHemolysisHumansHydrogen-Ion ConcentrationMolecular Docking SimulationProtein BindingBacterial ToxinsCholesterolHeat-Shock ProteinsHemolysin ProteinsHeparinhlyA protein, Listeria monocytogenescore ligandD4 domainheparan sulfateheparin-binding proteinsListeria monocytogeneslisteriolysin (LLO)-heparin interactionLLO purification
Identifiers
PMID42284445
PMCPMC13393555
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