In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Huizi WangDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0003-8907-3352 Licai ShiState Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.ORCID 0009-0001-6773-0775 Ke JiangCenter for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-7959-7716 Shuyao WuDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0005-7319-3127 Zhenyan JiangDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuexiao TaoDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3820-0553 Jia LiDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin LiDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0007-4012-8577 Jiamin LiuDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jun NiDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0002-6105-9455 Emily Jiatong WuDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0003-3848-4266 Sophia Jiaxin WuDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0006-3946-8307 Guang ChenState Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.
Ming QinDepartment of Immunology, Zunyi Medical University and Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi City, Guizhou Province 563000, China.ORCID 0000-0001-5633-3988 Lin XuDepartment of Immunology, Zunyi Medical University and Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi City, Guizhou Province 563000, China.ORCID 0000-0002-6889-0279 Chu-Hu LaiPrecision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Alexandra AicherPrecision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Youqiong YeDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-8332-4710 Christopher HeeschenPancreatic Cancer Heterogeneity, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, Italy.ORCID 0000-0002-1158-8554 Yu J CaoState Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.ORCID 0000-0003-4368-7757 Xuefeng WuDepartment of General Surgery, Tongren Hospital & Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-6933-7280 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Endoplasmic reticulum stress (ERS) and autophagy regulate tumor-infiltrating T cell function and exhaustion, but the underlying mechanisms remain unclear. Here, we identified the ERS-related transmembrane protein TMED4 (transmembrane emp24 domain-containing 4) as a critical regulator of CD8
Indexed as
AutophagyCD8-Positive T-LymphocytesEndoribonucleasesImmunotherapy, AdoptiveMembrane ProteinsNeoplasmsProtein Serine-Threonine KinasesAnimalsCell Line, TumorEndoplasmic Reticulum StressHumansMiceSignal TransductionT-Cell ExhaustionX-Box Binding Protein 1EndoribonucleasesERN1 protein, humanErn1 protein, mouseMembrane ProteinsProtein Serine-Threonine KinasesX-Box Binding Protein 1Xbp1 protein, mouse
Identifiers
PMID42284413
PMCPMC13262630
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390