Evidence map›Paper›PMID 42284410›Full record

ArticleScience advances2026

Coupling of cargo to the autophagy receptor is a critical step in ER-phagy.

Shuliang Chen, Subhrajit Banerjee, Dongmei Liu, Kamal Kumar, Christopher J Obara, Peter Novick, William A Prinz, Susan Ferro-Novick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuliang ChenDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7175-7604
Subhrajit BanerjeeDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1474-8864
Dongmei LiuDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Kamal KumarDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5171-894X
Christopher J ObaraDepartment of Pharmacology, Biochemistry, and Molecular Biophysics, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1028-6076
Peter NovickDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-0401-7857
William A PrinzDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9053-2398
Susan Ferro-NovickDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8714-7352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During cell stress, endoplasmic reticulum autophagy (ER-phagy) receptors remodel the ER by sequestering membrane proteins (cargo) into autophagosomes for degradation. The conserved ER-phagy receptor, Atg40, contains a motif that binds to Atg8 and a reticulon homology domain that is needed for vacuolar/lysosomal delivery. Cargo capture, however, requires the Atg40 binding partner Lst1/SEC24C. To address whether lipids regulate cargo capture during ER-phagy, we analyzed autophagy in neutral lipid-deficient cells. Unexpectedly, we found that Atg40 was delivered to the vacuole in autophagosomes without Lst1/SEC24C or cargo in mutant cells. Lipidomic analysis revealed changes in the ratio of phosphatidylethanolamine to phosphatidylcholine in the neutral lipid-deficient cells that are predicted to alter ER membrane bendability. Our findings imply that phospholipids control cargo sequestration by regulating receptor-cargo coupling at autophagic sites.

Indexed as

AutophagyAutophagy-Related ProteinsEndoplasmic ReticulumSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAutophagosomesMembrane ProteinsPhosphatidylethanolaminesProtein BindingProtein TransportVacuolesAutophagy-Related ProteinsMembrane ProteinsphosphatidylethanolaminePhosphatidylethanolaminesSaccharomyces cerevisiae Proteins

Identifiers

PMID42284410
PMCPMC13262609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.