Evidence map›Paper›PMID 42284327›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.

Ana Garoña, Morgane V Lemos, Andrea Giometto, Marco Fumasoni

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ana GaroñaGulbenkian Institute for Molecular Medicine, Oeiras 2780-156, Portugal.
Morgane V LemosGulbenkian Institute for Molecular Medicine, Oeiras 2780-156, Portugal.ORCID 0009-0002-2763-4540
Andrea GiomettoSchool of Civil and Environmental Engineering, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-0544-6023
Marco FumasoniGulbenkian Institute for Molecular Medicine, Oeiras 2780-156, Portugal.ORCID 0000-0002-4507-7824

Funding

Evolutionary dynamics of dense, spatially structured, and antagonistic microbial populationsR35GM147493 · NIGMS · CORNELL UNIVERSITY · PI Andrea Giometto · 2022 to 2026
$2.0M
European Molecular Biology Organization (EMBO) IG 5349-2023Fundação Calouste Gulbenkian (Calouste Gulbenkian Foundation) CoreFundsHHS | NIH | National Institute of General Medical Sciences (NIGMS) 1R35GM147493Human Frontier Science Program (HFSP) RGEC28/2023MEC | Fundação para a Ciência e a Tecnologia (FCT) 2023.09068.CEECINDNIGMS NIH HHS R35 GM147493
6 · The paper itself

Abstract

Cell volume, a key determinant of physiology, is maintained by cell size homeostasis. Large deviations from typical size are often harmful, yet cell sizes have diverged drastically during evolution. How size homeostasis evolves to support such diversity without impairing cellular function remains unclear. To address this question, we used experimental evolution to progressively select for smaller

Indexed as

Biological EvolutionCell SizeSaccharomyces cerevisiaeCyclinsHomeostasisMutationSaccharomyces cerevisiae ProteinsSignal TransductionTOR Serine-Threonine KinasesCLN3 protein, S cerevisiaeCyclinsSaccharomyces cerevisiae ProteinsTOR Serine-Threonine Kinasescell cyclecell sizeevolutionary cell biologyexperimental evolutionS. cerevisiae

Identifiers

PMID42284327
PMCPMC13273275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.