Evidence map›Paper›PMID 42284150›Full record

ArticleJournal of medicinal chemistry2026

Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in

Eleonora Diamanti, Amelieke J H Cremers, Yue Li, Ioulia Exapicheidou, Carole Baumann, Paddy Gibson, Atanaz Shams, Louise Martin, Rouven Becker, Inda Setyawati and 9 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eleonora DiamantiHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.ORCID 0000-0001-8392-5575
Amelieke J H CremersDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Yue LiGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen 9747AG, The Netherlands.
Ioulia ExapicheidouHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Carole BaumannHelmholtz Institute for Pharmaceutical Research (HIPS) -Helmholtz Centre for Infection Research (HZI)Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Paddy GibsonDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Atanaz ShamsHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Louise MartinDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Rouven BeckerHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Inda SetyawatiGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen 9747AG, The Netherlands.ORCID 0000-0001-9861-1755
Lucie ZeimetzHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.
Matthias WitschelBASF-SECarl-Bosch-Strasse 38, Ludwigshafen 67056, Germany.ORCID 0000-0003-0537-5146
Dirk J SlotboomGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen 9747AG, The Netherlands.ORCID 0000-0002-5804-9689
Jennifer HerrmannHelmholtz Institute for Pharmaceutical Research (HIPS) -Helmholtz Centre for Infection Research (HZI)Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.ORCID 0000-0003-3398-9938
Katharina RoxDepartment of Chemical Biology, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, Braunschweig 38124, Germany.ORCID 0000-0002-8020-1384
Mostafa M HamedHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.ORCID 0000-0002-7374-6992
Jan-Willem VeeningDepartment of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Anna K H HirschHelmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, Saarbrücken, Saarland D-66123, Germany.ORCID 0000-0001-8734-4663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Energy-Coupling Factor (ECF) transporters are a hitherto underexplored target involved in the uptake of several micronutrients in bacteria and are absent in humans. Here, in

Indexed as

Anti-Bacterial AgentsBacterial ProteinsMembrane Transport ProteinsStreptococcus pneumoniaeAnimalsHumansMiceMicrobial Sensitivity TestsPneumococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsMembrane Transport Proteins

Identifiers

PMID42284150
PMCPMC13312444

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.