Evidence map›Paper›PMID 42284071›Full record

ArticleBiochemistry2026

PAX3-FOXO1 Contacts BRD4 through Its Acetylated Intrinsically Disordered Region.

Olivia A Fraser, Madeline N Schleicher, Maya L Pagano, Scott A Showalter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia A FraserDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Madeline N SchleicherDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Maya L PaganoDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Scott A ShowalterDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-5179-032X

Funding

Eukaryotic Gene Regulation (EGR) Predoctoral Training ProgramT32GM125592 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI REESE, JOSEPH C · 2018 to 2022
$920k
Acetyllysine Structure-Function Analysis by 13C Direct-Detect NMR SpectroscopyR01GM157622 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Scott A Showalter · 2025 to 2026
$698k
Pilot Studies of PAX3-FOXO1 Fusions Proteins in Alveolar RhabdomyosarcomaR03TR004687 · NCATS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SHOWALTER, SCOTT A · 2023 to 2023
$156k
NCATS NIH HHS R03 TR004687NIGMS NIH HHS R01 GM157622NIGMS NIH HHS T32 GM125592
6 · The paper itself

Abstract

Intrinsically disordered regions (IDRs) of transcription factors are frequent sites for post-translational modifications (PTMs), which mediate regulation through diverse mechanisms including protein-protein interactions. In the fusion oncoprotein PAX3-FOXO1, which drives alveolar rhabdomyosarcoma, a lysine-rich region of the FOXO1 IDR is subject to acetylation resulting in stabilization and enhanced transcriptional activity. Here, we leveraged

Indexed as

Cell Cycle ProteinsForkhead Box Protein O1Intrinsically Disordered ProteinsNuclear ProteinsOncogene Proteins, FusionTranscription FactorsAcetylationAnimalsAzepinesBromodomain Containing ProteinsHumansPaired Box Transcription FactorsProtein BindingProtein DomainsProtein Processing, Post-TranslationalTriazolesAzepinesBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsForkhead Box Protein O1Intrinsically Disordered Proteins(+)-JQ1 compoundNuclear ProteinsOncogene Proteins, FusionPaired Box Transcription FactorsPAX3-FOXO1A fusion protein, humanTranscription FactorsTriazoles

Identifiers

PMID42284071
PMCPMC13348024

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.