ArticleEJNMMI physics2026
Impact of scan duration and scatter correction on quantitative accuracy in Yttrium-90 PET/CT imaging using LAFOV and SAFOV systems: a phantom and clinical evaluation.
Article in EJNMMI physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study compared quantitative accuracy and image quality of post-radioembolization selective internal radiation therapy (SIRT)
methodsPhantom experiments were conducted on Biograph Vision Quadra (LAFOV) and Vision 600 (SAFOV) PET/CT scanners using NEMA IQ phantoms filled with
resultsLAFOV achieved higher RCs and ~ 3× lower BV than SAFOV. ABS yielded significantly improved accuracy and stability versus RS, particularly at short scans. Patient data acquired on the LAFOV system showed ABS quantification equivalent to injected activity within ± 10% for ≥ 5 min (CCC ≥ 0.99), whereas RS required ≥ 10 min. Variance followed a power-law decay (γ ≈ 1.5 at 5 min), and logistic regression identified an activity threshold of ~ 1.6 GBq for 90% accuracy at 5 min. At ≥ 10 min, quantification became independent of activity.
conclusionCompared with a SAFOV 50-minute clinical routine acquisition, LAFOV PET enabled a similar BV performance at 7-times accelerated scanning duration. LAFOV PET/CT with absolute scatter correction enables accurate
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