ArticleBrain informatics2026
A feasibility study on inferring connectivity changes in frontal lobes of MDD patients via spectral DCM.
Article in Brain informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Many studies have shown that major depressive disorder (MDD) is highly relevant to the dysfunction of frontal lobes. Given the crucial role of brain network organization for MDD, this work focuses on inferring effective connectivity patterns and their changes in the frontal lobes of non-depressive and MDD subjects. We collected frontopolar left (Fp1), frontopolar right (Fp2), and frontal midline (Fz) channels of resting electroencephalogram (EEG) from 22 subjects with non-depressive states (non-depressive group), 23 subjects with mild depression (mild MDD group) and 12 subjects with moderate depression (moderate MDD group). Complete Physiology-Based Model was introduced to simulate the EEG signals of brain activities in the three targeted lobes. Then, spectral dynamic causal modelling was performed to investigate effective connectivity and its changes between the three targeted channels. The findings suggest that MDD groups exhibit a significant decline in the average strength of excitatory connectivity between pyramidal cells of the three lobes, compared to the non-depressed group. Additionally, the fluctuation of connectivity across trials among frontal lobes decreases in the mild and moderate MDD groups. The MDD groups also showed frontal asymmetry, specifically in the form of significant differences in bidirectional excitatory connections between Fp1 and Fp2. These effective connectivity changes of frontal lobes may indicate its clinical potential in future research on depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.