Evidence map›Paper›PMID 42283949›Full record

ArticleTropical animal health and production2026

Administration of antioxidants at parturition in Italian Mediterranean lactating buffaloes: findings in the postpartum.

Lorenza Frattina, Alice Carbonari, Matteo Burgio, Giovanni Bramante, Olga Maria Andriulo, Edmondo Ceci, Ciro Galdieri, Antonietta D'Onghia, Vincenzo Cicirelli, Annalisa Rizzo

Abstract read
In one paragraph

Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorenza FrattinaDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0009-0005-9422-4746
Alice CarbonariDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0000-0002-1287-478X
Matteo BurgioDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy. matteo.burgio@uniba.it.ORCID http://orcid.org/0000-0002-8203-4540
Giovanni BramanteDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0009-0000-8620-9320
Olga Maria AndriuloDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0009-0000-4250-2875
Edmondo CeciDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0000-0002-5496-4855
Ciro GaldieriDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.
Antonietta D'OnghiaAssociazione Regionale Allevatori Puglia, Strada Comunale San Nicola 2, 70017, Putignano, BA, Italy.
Vincenzo CicirelliDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0000-0003-2792-8848
Annalisa RizzoDepartment of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010, Valenzano, BA, Italy.ORCID http://orcid.org/0000-0002-2688-0056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transition period is an extremely critical phase for the Mediterranean lactating buffaloes, characterized by a state of oxidative stress. Oral administration of antioxidants is common. However, the aim of this study was to evaluate whether the intramuscular administration of a vitamin combination, containing α-tocopherol and β-carotene, could improve both milk quality and reproductive performance. The animals were divided into two groups: a group treated, at 24 h postpartum, with a vitamin combination (group D) and a control group (C). For milk quality, concentrations of retinol, α-tocopherol, fat, protein, lactose, Somatic Cell Count (SCC), non-fat dry matter (NFDM), casein, urea, pH, satured fatty acids (SFA), unsaturated fatty acids (UFA), monounsaturated fatty acids (MUFA) and poliunsaturated fatty acids (PUFA) in milk were assessed at 7 and 30 days post-treatment. Reproductive performance was evaluated using two parameters: pregnancy rate and the calving-conception interval. Retinol concentrations did not differ significantly between groups or across time points. α-tocopherol levels were significantly higher in group D compared to group C at T30 (0.35 ± 0.016 vs. 0.27 ± 0.015 mg/100 g; p < 0.05), whereas in group C exhibited a significant decrease over time. Fat, SFA, UFA, MUFA, and PUFA levels were significantly elevated in group D relative to group C (p < 0.05), while SCC showed a significant reduction in the treated group than the control one (104.4 ± 20.12 vs. 136.6 ± 32.24 × 10³ cells/mL; p < 0.05). No significant differences were observed in pregnancy rates; however, the calving-conception interval was significantly shortened in group D (62.23 ± 6.17 vs. 72.88 ± 5.49 days; p < 0.01). The obtained results indicate that the parenteral administration of the vitamin combination was associated with changes in selected milk quality parameters and with a shorter calving-conception interval.

Indexed as

alpha-TocopherolAntioxidantsbeta CaroteneBuffaloesLactationMilkAnimalsFemaleInjections, IntramuscularItalyParturitionPostpartum PeriodPregnancyVitamin Aalpha-TocopherolAntioxidantsbeta CaroteneVitamin ABuffaloesPostpartumReproductive performanceα-tocopherolβ-carotene

Identifiers

PMID42283949
PMCPMC13263305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.