Evidence map›Paper›PMID 42283888›Full record

ArticleJournal of computer-aided molecular design2026

Anticonvulsant activity of aza-Biginelli derivatives related to JM-II-43A and HSAB-based rationalization of their pharmacological profile.

Hulme Ríos-Guerra, Harold Alexis Prada-Ramírez, Benjamín Velasco-Bejarano, Margarita López-Martínez, Judith Espinosa Espinosa-Raya, Alfredo Briones-Arandas, René Miranda-Ruvalcaba, María Inés Nicolás-Vázquez, Raquel Gómez-Pliego

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hulme Ríos-GuerraLaboratorio de Química Multicomponente, Sección de Química Orgánica, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Campo 1, Universidad Nacional Autónoma de México, Av. 1ero de Mayo S/N, Santa María Guadalupe las Torres, C.P. 54740, Cuautitlán Izcalli, Estado de México, México.ORCID http://orcid.org/0000-0002-8606-3808
Harold Alexis Prada-RamírezUniversidad de los Andes, Bogotá Cundinamarca, Colombia.ORCID http://orcid.org/0000-0003-3490-5329
Benjamín Velasco-BejaranoLaboratorio de Química Medicinal Verde, Sección de Química Orgánica, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Campo 1, Universidad Nacional Autónoma de México, Av. 1ero de Mayo S/N, Santa María Guadalupe las Torres, C.P. 54740, Cuautitlán Izcalli, Estado de México, México.ORCID http://orcid.org/0000-0002-2934-8698
Margarita López-MartínezDepartamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Montes Urales 800, Col. Lomas de Virreyes, C.P. 11000, Miguel Hidalgo, Ciudad de México, México.
Judith Espinosa Espinosa-RayaLaboratorio Multidisciplinario en Ciencias Biomédicas, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón S/N, C.P. 11340, Miguel Hidalgo, Ciudad de México, México.ORCID http://orcid.org/0000-0002-3181-2920
Alfredo Briones-ArandasLaboratorio de Farmacología, Facultad de Medicina Humana, Universidad Autónoma de Chiapas, Décima Sur, esquina con calle Central S/N, C.P. 29000, Tuxtla Gutiérrez, Chiapas, México.ORCID http://orcid.org/0000-0002-0628-2446
René Miranda-RuvalcabaLaboratorio de Investigación en Química Orgánica-Verde, Sección de Química Orgánica, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Campo 1, Universidad Nacional Autónoma de México, Av. 1ero de Mayo s/n, Santa María Guadalupe las Torres, C.P. 54740,, Cuautitlán Izcalli, Estado de México, México.ORCID http://orcid.org/0000-0002-1979-5590
María Inés Nicolás-VázquezLaboratorio de Química Computacional, Sección de Química Inorgánica, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Campo 1, Universidad Nacional Autónoma de México, Av. 1ero de Mayo S/N, Santa María Guadalupe las Torres, 54740, Cuautitlán Izcalli, Estado de México, México. nicovain@comunidad.unam.mx.ORCID http://orcid.org/0000-0003-0722-5045
Raquel Gómez-PliegoLaboratorio de Microbiología Industrial, Sección de Ciencias de la Salud Humana, Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Campo 1, Universidad Nacional Autónoma de México, Av. 1ero de Mayo S/N, Col. Santa María Guadalupe las Torres, C.P. 54740, Cuautitlán Izcalli, Estado de México, México. pliegoraquel@comunidad.unam.mx.ORCID http://orcid.org/0000-0002-6227-0511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the nitrogen-containing heterocyclic compounds proposed as selective modulators of γ-aminobutyric acid type A (GABA

Indexed as

AnticonvulsantsAza CompoundsPyrimidinonesReceptors, GABA-ASeizuresAnimalsMaleMiceStructure-Activity RelationshipAnticonvulsantsAza CompoundsPyrimidinonesReceptors, GABA-AAnticonvulsant activityAza-Biginelli productsHSAB parametersPentylenetetrazole modelQuantum mechanical method

Identifiers

PMID42283888
PMCPMC13263284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.