Evidence map›Paper›PMID 42283820›Full record

ArticleJournal of medicinal chemistry2026

(

Michela Puxeddu, Zeyu Cui, Claudia Colla, Marianna Nalli, Simone Manetto, Alessia Ciogli, Petra Cuřínová, Marianna Bufano, Angelo Toto, Stefano Gianni and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Michela PuxedduLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0002-0024-596X
Zeyu CuiShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai200031, China.
Claudia CollaLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.
Marianna NalliLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.
Simone ManettoLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.
Alessia CiogliLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0002-7538-2424
Petra CuřínováDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 616628, Czech Republic.ORCID 0000-0001-8264-7032
Marianna BufanoDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 616628, Czech Republic.
Angelo TotoLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Biochemical Sciences "Rossi Fanelli", Institute of Biology and Molecular Pathology of CNR, Sapienza Università di Roma, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0002-4620-3677
Stefano GianniLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Biochemical Sciences "Rossi Fanelli", Institute of Biology and Molecular Pathology of CNR, Sapienza Università di Roma, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0003-1653-1925
Arianna PastoreDepartment of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, 49, Naples80131, Italy.
Mariano StornaiuoloDepartment of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, 49, Naples80131, Italy.ORCID 0000-0003-2200-5083
Enke BaldiniDepartment of Surgery, Sapienza University of Rome, Viale Regina Elena 324, Rome00185, Italy.
Salvatore UlisseDepartment of Surgery, Sapienza University of Rome, Viale Regina Elena 324, Rome00185, Italy.
Joanna KopeckaDepartment of Oncology and Molecular Biotechnology Center ″Guido Tarone″, Via Nizza 44, Turin10126, Italy.
Chiara RigantiDepartment of Oncology and Molecular Biotechnology Center ″Guido Tarone″, Via Nizza 44, Turin10126, Italy.ORCID 0000-0001-9787-4836
Chiara BigognoAphad SrL, Via della Resistenza 65, Buccinasco20090, Italy.
Giulio DondioAphad SrL, Via della Resistenza 65, Buccinasco20090, Italy.ORCID 0000-0001-5023-3804
Te LiuShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai200031, China.
Antonio ColucciaLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0002-7940-8206
Giuseppe La ReginaLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0003-3252-1161
Romano SilvestriLaboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome00185, Italy.ORCID 0000-0003-2489-0178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dishevelled (DVL) proteins are key mediators of the Wnt/β-catenin signaling pathway, involved in signal transduction from membrane receptors to intracellular effectors. DVL up-regulation has often been correlated with tumor progression and metastasis. DVL1 was found overexpressed in multidrug-resistant colorectal cancer (CRC) cells. Here, we describe the synthesis of new indole-2-carboxamides

Indexed as

Antineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Dishevelled ProteinsIndolesAnimalsCell Line, TumorHCT116 CellsHumansMiceMice, NudeStructure-Activity RelationshipXenograft Model Antitumor AssaysAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Dishevelled ProteinsIndoles

Identifiers

PMID42283820
PMCPMC13312410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.