Evidence map›Paper›PMID 42283792›Full record

ReviewNeurochemical research2026

Rotenone in Drug-Resistant Epilepsy Models: Powerful Tool or Problematic Paradigm?

Nidhi Khedpande, Kalyani Barve

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nidhi KhedpandeDepartment of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-University, Mumbai, 400056, India.
Kalyani BarveDepartment of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-University, Mumbai, 400056, India. kalyani.barve@nmims.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rotenone adjuvant kindling paradigm replicates key clinical features of drug-resistant epilepsy (DRE), including broad-spectrum pharmacoresistance, neuroinflammation, and oxidative stress, by combining mitochondrial complex I inhibition with pentylenetetrazol (PTZ) or corneal kindling. PTZ, a GABA

Indexed as

Disease Models, AnimalDrug Resistant EpilepsyRotenoneAnimalsHumansKindling, NeurologicMitochondriaPentylenetetrazolePentylenetetrazoleRotenoneDrug-resistant epilepsyMitochondrial dysfunctionNeuroinflammationPharmacoresistanceRotenone adjuvant kindling

Identifiers

PMID42283792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.