ArticleJACC. Case reports2026
Severe Hypertriglyceridemia Managed in a Pregnant Patient Using Nonstatin Therapies.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundSevere hypertriglyceridemia (HTG) in pregnancy is associated with increased maternal-fetal morbidity. Treatment options remain limited because of fetal safety concerns. CASE SUMMARY: A 34-year-old pregnant patient with type 2 diabetes mellitus and HTG was referred to our cardio-obstetrics multidisciplinary team for management of HTG at 16 weeks of gestation. She was managed with omega-3 acid ethyl esters, insulin, and lifestyle modifications, with improvement in levels noted over 4 months. DISCUSSION: This case highlights the complexities of managing severe HTG in pregnancy. Although many lipid-lowering agents are avoided during pregnancy, high-risk women with concurrent type 2diabetes mellitus may be treated with insulin and omega-3 fatty ethyl esters. TAKE-HOME MESSAGES: Severe HTG in pregnancy is associated with increased risk of maternal-fetal morbidity. Management of severe HTG in pregnancy includes preconception risk assessment, multidisciplinary care, intensive lifestyle modification, selective use of nonstatin agents, and monitoring throughout and after pregnancy.
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