Highly pathogenic porcine reproductive and respiratory syndrome virus nonstructural protein 1 interacts with TRAF6 to activate the TAK1/p38/JNK/AP-1 signaling and induce IL-1β.

Jiaying Zhu, Shuyuan Guo, Ailing Liang, Chang Liu, Hao Zhou, Zhongzhou Chen, Wen-Hai Feng

Abstract read

In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaying ZhuFrontiers Science Center for Molecular Design Breeding, Beijing, China.

Shuyuan GuoFrontiers Science Center for Molecular Design Breeding, Beijing, China.

Ailing LiangState Key Laboratory of Animal Biotech Breeding, Beijing, China.

Chang LiuFrontiers Science Center for Molecular Design Breeding, Beijing, China.

Hao ZhouFrontiers Science Center for Molecular Design Breeding, Beijing, China.

Zhongzhou ChenState Key Laboratory of Animal Biotech Breeding, Beijing, China.ORCID 0000-0003-1319-9664

Wen-Hai FengFrontiers Science Center for Molecular Design Breeding, Beijing, China.ORCID 0000-0001-8151-6698

Funding

National Key Research and Development Program of China 2022YFD1800300National Key Research and Development Program of China 2023YFF1000901

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is a highly contagious disease that severely threatens the global pig industry. A significant symptom of PRRS is severe pneumonia. At present, studies have shown that IL-1β is upregulated by PRRSV infection

Indexed as

Interleukin-1betaPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusTNF Receptor-Associated Factor 6Transcription Factor AP-1Viral Nonstructural ProteinsAnimalsCell LineMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesProtein BindingSignal TransductionSwineInterleukin-1betaMAP Kinase Kinase Kinase 7MAP Kinase Kinase Kinasesp38 Mitogen-Activated Protein KinasesTNF Receptor-Associated Factor 6Transcription Factor AP-1Viral Nonstructural ProteinsIL-1βinflammationMAPK pathwaysnsp1PRRSV

Identifiers

PMID42283627

DOI10.1128/jvi.00428-26

PMCPMC13386909

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.