Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Shumin WangAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0003-0217-6600
Meera V SinghDepartment of Neurology (M.V.S., G.S.), University of Rochester School of Medicine and Dentistry, Rochester, NY.ORCID 0000-0001-8481-1668
Craig N MorrellAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0001-9131-4862
Hongmei YangDepartment of Biostatistics and Computational Biology (H.Y., A.T.), University of Rochester School of Medicine and Dentistry, Rochester, NY.ORCID 0000-0002-8547-3207
Jordan RhenAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0002-5110-4438
Tengge WangAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0009-0002-4835-5786
Laith Awad MohamadAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).
Jasmine Jiayuan XuAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).
Tiffany NguyenAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0002-6750-2051
Sara TureAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0003-0568-8791
Alicia TyrellDepartment of Biostatistics and Computational Biology (H.Y., A.T.), University of Rochester School of Medicine and Dentistry, Rochester, NY.ORCID 0009-0002-1197-345X
Jinghan ZhangDepartment of Obstetrics and Gynecology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Jiangsu, China (J.Z.).
Sanjay B MaggirwarDepartment of Microbiology, Immunology, and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, DC (S.B.M.).ORCID 0000-0003-4948-917X
Giovanni SchifittoDepartment of Neurology (M.V.S., G.S.), University of Rochester School of Medicine and Dentistry, Rochester, NY.ORCID 0000-0002-2115-4143
Jinjiang PangAab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., C.N.M., J.R., T.W., L.A.M., J.J.X., T.N., S.T., J.P.).ORCID 0000-0001-6946-3941
Funding
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
University of Rochester CTSA HubUM1TR005451 · NCATS · UNIVERSITY OF ROCHESTER · PI Karen M. Wilson, Martin S Zand · 2025 to 2026
$7.0M
The novel mechanisms of HIV associated vascular cognitive impairmentR01HL122777 · NHLBI · UNIVERSITY OF ROCHESTER · PI PANG, JINJIANG · 2014 to 2023
$4.1M
Role of Myeloid Cells in Cerebrovascular Permeability and Reactivity in Older HIV Infected IndividualsR01AG054328 · NIA · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B., SCHIFITTO, GIOVANNI · 2017 to 2021
$3.5M
Brain Structural and Functional Connectome in HIV-Associated NeuroinflammationR01MH118020 · NIMH · UNIVERSITY OF ROCHESTER · PI SCHIFITTO, GIOVANNI · 2018 to 2023
$3.4M
Role of platelet- monocyte interaction in promoting pro-atherogenic state in HIV-infected individualsR01HL160229 · NHLBI · UNIVERSITY OF ROCHESTER · PI Meera Vir Singh, Juilee Thakar · 2022 to 2026
$2.6M
Role of Monocyte Delta Like-4 (Dll4) in HIV-Associated Cerebral Small Vessel DiseaseR01NS132870 · NINDS · UNIVERSITY OF ROCHESTER · PI Jinjiang Pang, GIOVANNI SCHIFITTO · 2024 to 2026
$2.3M
Tissue Dependent Megakaryocyte FunctionsR01HL160610 · NHLBI · UNIVERSITY OF ROCHESTER · PI MORRELL, CRAIG N · 2022 to 2025
$2.0M
Platelet Regulation of Monocyte Responses in Vascular InflammationR01HL176697 · NHLBI · UNIVERSITY OF ROCHESTER · PI CRAIG N MORRELL · 2025 to 2026
backgroundIn people living with HIV (PLWH), persistent systemic inflammation drives comorbidities, including cardiovascular and cerebrovascular diseases. Monocyte-mediated inflammation, rather than T-cell activation, is a major contributor to chronic inflammation. However, the underlying mechanisms remain elusive. Here, we investigated the role of Dll4 (delta-like 4)-Notch signaling in monocyte-mediated inflammation.
methodsIn clinical specimens, we quantified monocyte mDll4 (membrane-bound Dll4) expression and plasma levels of exDll4 (extracellular Dll4). We also analyzed the association between circulating exDll4 and monocyte subsets in PLWH. In vitro, human primary monocytes, endothelial cells, and T cells were stimulated with lipopolysaccharide or TNF-α (tumor necrosis factor-α) to assess
resultsBoth male and female PLWH exhibited significantly increased mDll4 expression, activation of Dll4-Notch1 signaling, and increased Notch-targeted inflammatory factors. Although monocyte mDll4 did not differ by sex in PLWH, plasma exDll4 was significantly elevated in males, but not females, compared with HIV-uninfected individuals. In male PLWH, plasma exDll4 levels paralleled monocyte mDll4 expression. Circulating exDll4 was positively associated with proinflammatory monocytes and negatively associated with classical monocytes in male PLWH. Mechanistically, lipopolysaccharide or TNF-α robustly increased
conclusionsProinflammatory cues upregulate Dll4 in monocytes and activate Dll4-Notch signaling, thereby suppressing antiviral responses and enhancing monocyte transmigration. Together, these effects sustain systemic inflammation in PLWH of both sexes. Our data identify monocyte-derived Dll4 as a promising biomarker and therapeutic target for systemic inflammation.
Indexed as
Adaptor Proteins, Signal TransducingCalcium-Binding ProteinsHIV InfectionsInflammationMonocytesAdultCells, CulturedFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedReceptor, Notch1Signal TransductionAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanIntracellular Signaling Peptides and ProteinsNOTCH1 protein, humanReceptor, Notch1DLL4 protein, humanHIVinflammationinterferonmonocytereceptor, Notch1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Monocyte Dll4 Contributes to Systemic Inflammation in People Living With HIV. · full record | OpenQuestion