ArticleBiomaterials research2026
Transdermal Delivery of Chinese Medicinal Formula Mitigates Pediatric Constipation by Modulating Intestinal Endocrine and Metabolic Homeostasis.
Article in Biomaterials research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pediatric constipation, attributed to the functional immaturity of the gastrointestinal tract in children, is a common clinical disorder characterized by impaired gastrointestinal motility and infrequent bowel movements. Existing therapeutic strategies are frequently constrained by suboptimal efficacy owing to their single-target mechanisms and systemic toxicity. In contrast, Chinese medicinal formulas, with their multicomponent and multitarget intervention strategies, offer a highly suitable alternative for managing constipation. The traditional Chinese medicine formula "YiNianJin" (YNJ) is composed of cinnabar, rhubarb, stir-fried morning glory seeds, areca nut, and ginseng. It has demonstrated significant therapeutic efficacy in accelerating intestinal peristalsis through the synergistic regulation of aquaporin expression and the release of endocrine homeostatic transmitters. However, the clinical application of YNJ is significantly limited by conventional oral administration, which leads to Hg
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