ArticleJournal of oral microbiology2026
Microbiome dynamics and early microbial signatures predict bone regeneration in marsupialized jaw lesions: a longitudinal 16S sequencing cohort study.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Marsupialization is a conservative treatment for odontogenic jaw lesions but is hampered by protracted, unpredictable bone regeneration, lacking early biomarkers. Furthermore, whether these intraosseous lesions harbour a unique microbiome remains unknown. We aimed to characterize microbial dynamics during treatment and develop a prognostic model to address clinical unpredictability. Methods: A prospective longitudinal study was conducted with multi-site sampling (saliva, tissue, luminal fluid and swabs) across three phases: primary surgery, 3-month follow-up and secondary surgery. Bacterial 16S rRNA gene sequencing was subsequently performed. Microbial dynamics were analyzed using diversity analysis and source tracking. A prognostic model was constructed using a hybrid feature selection strategy to predict 12-month bone regeneration using 3-month post-operative swabs. Results: Baseline analysis revealed that odontogenic jaw lesions harbour a unique, biologically selected microbiome enriched in Conclusion: Marsupialization drives the lesion microbiome from a pathogenic niche toward a stochastic, commensal-like state. This succession trajectory is associated with clinical outcome. Our prognostic model offers a novel precision tool to optimize lesion management.
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