ArticlePNAS nexus2026
Active and probe-free intracellular rheology via phase-sensitive thermoviscous flows.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Determination of the rheological properties of cells is known to require active measurements, which largely depend on the internalization of mechanical probes. Here, we circumvent this problem via the introduction of Rheological focused light-induced cytoplasmic streaming (Rheo-FLUCS): an active, yet probe-free approach that leverages light-induced flows to access mechanical changes in complex systems. While Rheo-FLUCS is facilitated by thermoviscous expansion phenomena rather than external forces, here we show equivalence in its ability to measure relative viscoelastic properties. Specifically, we demonstrate a phase-lag equivalence with probe-dependent active microrheology in a wide range of physically different, yet chemically identical materials. We exemplify the utility of Rheo-FLUCS in three distinctly different biological systems: compound-treated mouse fibroblasts (NIH-3T3), genetically modified human osteoblasts (U2OS) to elucidate the role of myosins in cytoplasmic mechanics, and early ascidian oocytes of
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