Evidence map›Paper›PMID 42282916›Full record

ArticleGastroenterology research and practice2026

Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function.

Mark Kern, Francis Edeani, Ling Mei, Patrick Sanvanson, Reza Shaker

Abstract read
In one paragraph

Article in Gastroenterology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark KernDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, mcw.edu.
Francis EdeaniDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, mcw.edu.
Ling MeiDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, mcw.edu.
Patrick SanvansonDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, mcw.edu.
Reza ShakerDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, mcw.edu.ORCID https://orcid.org/0000-0001-6079-1017

Funding

Deglutitive and airway protective functions of proximal/ striated muscle esophagus in health and diseaseR01DK132082 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2022 to 2025
$1.8M
NIDDK NIH HHS R01 DK132082
6 · The paper itself

Abstract

Introduction: Effects of aging on the relationship of striated esophagus (StEso) motor function with pharyngeal deglutitive biomechanics has not been systematically studied. Objective: The aim of this study is to characterize the effects of aging on the correlation of deglutitive StEso with pharyngeal function. Materials and Methods: We studied 33 healthy subjects. Fifteen elderly (age: 75 ± 7 years, 8 female) and 18 nonelderly (age: 50 ± 14 years, 9 F) were evaluated using high resolution manometry/impedance. Nine elderly (73 ± 7 years, 5 F) and eight young (24 ± 3 years, 4 F) were further evaluated by digital videofluoroscopy. Results and Discussion: Duration of StEso excursion averaged 2.56 ± 0.65 s in elderly and 2.33 ± 0.41 in young. We identified four periods in StEso motor function during deglutitive excursion: (a) anterosuperior ascent without bolus/peristaltic activity, (b) nonperistaltic bolus receiving function at apogee of StEso excursion during UES opening and pharyngeal peristalsis, (c) peristaltic bolus transport as StEso descends, (d) continued peristalsis in resting position. Apart from the final period described, the periods are significantly different in the elderly compared with the young subjects ( Conclusions: Sequencing of StEso/pharyngeal deglutitive motor function is preserved in the elderly. The differences observed in early stages of spatiotemporal mapping of StEso deglutitive motor function when comparing healthy elderly to young populations may be due to age-related suprahyoid muscle weakness since the affected periods are those associated with the active StEso ascent and descent. Like young individuals, elderly pressure signatures currently attributed to the StEso deglutitive motor activity do not represent the entirety of StEso peristalsis.

Indexed as

agingmanometryperistalsispharynxstriated muscle esophagus

Identifiers

PMID42282916
PMCPMC13250628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.