Evidence map›Paper›PMID 42282903›Full record

ArticleSmall structures2025

Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers.

Julie Borchers, Kathryn Krycka, Brianna Bosch-Santos, Eduardo de Lima Correa, Anirudh Sharma, Hayden Carlton, Yanliu Dang, Michael Donahue, Cordula Grüttner, Robert Ivkov and 1 more

Abstract read
In one paragraph

Article in Small structures, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julie BorchersNIST Center for Neutron Research, National Institute of Standards and Technology Gaithersburg, MD 20899-6102, USA.
Kathryn KryckaNIST Center for Neutron Research, National Institute of Standards and Technology Gaithersburg, MD 20899-6102, USA.
Brianna Bosch-SantosMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8552, USA.
Eduardo de Lima CorreaMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8552, USA; Theiss Research, La Jolla, CA 92037, USA.
Anirudh SharmaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Hayden CarltonDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Yanliu DangMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8552, USA.
Michael DonahueInformation Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Cordula Grüttnermicromod Partikeltechnologie, GmbH, 18057 Rostock, Germany.
Robert IvkovDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Cindi L DennisMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8552, USA.

Funding

Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
ICP-QQQS10OD030355 · OD · JOHNS HOPKINS UNIVERSITY · PI RULE, ANA MARIA · 2021 to 2021
$350k
NCI NIH HHS R01 CA247290NCI NIH HHS R01 CA257557NIH HHS S10 OD026740NIH HHS S10 OD030355
6 · The paper itself

Abstract

Magnetic nanoparticles are indispensable in many biomedical applications, but it remains unclear how the composition and structure will influence the application specific performance. We consider two compositions, ferrite and cobalt ferrite, synthesized under conditions that create aggregated multi-core nanoparticles, called nanoflowers. Each nanoflower has an ionic surfactant or dextran to provide colloid stability in water. The composition, but not the coating, greatly impacts the heating output and the magnetic particle imaging tracer quality (with cobalt ferrite significantly reduced compared to ferrite). The cobalt ferrite nanoflowers have a core/shell structure with a reduced magnetization, which limits the effective magnetic anisotropy of the individual cobalt ferrite nanoflowers as well as the magnetic interactions among the nanoflowers. Both limitations significantly reduce the overall increase in the magnetic anisotropy with increasing magnetic field and consequently the nanoflowers' efficacy for heating and imaging. Despite this, the formation of denser-packed clusters and chains with external magnetic field in the ionic surfactant-cobalt ferrite nanoflowers overcomes some of the shell's detrimental effects, resulting in better heating and imaging properties compared to the dextran-cobalt ferrite. In short, the magnetic anisotropy dominates over physical and magnetic structure in the performance of the studied nanoflowers for heating and imaging applications.

Indexed as

magnetic anisotropymagnetic nanoparticlesnanoflowerssmall angle neutron scattering

Identifiers

PMID42282903
PMCPMC13251730

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.