Evidence map›Paper›PMID 42282899›Full record

ArticleGeromedicine2026

Excessive GABAergic activity in striatal and frontal cortical regions more than dopaminergic functions are related to daytime sleepiness in Parkinson's disease: An exploratory 11C-flumazenil PET study.

Robert Vangel, Stiven Roytman, Madhusudan Reddy, August Van Hout, Mélanie L Beaulieu, Giulia Carli, Peter J H Scott, Prabesh Kanel, Nicolaas I Bohnen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Geromedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert VangelDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Stiven RoytmanDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Madhusudan ReddyDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
August Van HoutDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Mélanie L BeaulieuDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Giulia CarliDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Prabesh KanelDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 1985 to 2012
$13.0M
Modulation of GABA-A Receptors and Axial Motor Impairments in Parkinson DiseaseR01NS099535 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2017 to 2020
$2.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
NINDS NIH HHS P01 NS015655NINDS NIH HHS R01 NS070856NINDS NIH HHS R01 NS099535RRD VA I01 RX000317
6 · The paper itself

Abstract

Aims: Increased gamma-aminobutyric acid type A (GABA Methods: Six PD patients underwent [ Results: Mean ESS score was 12.7 ± 4.5. Mean levodopa equivalent dose (LED) was 1,170 ± 616 mg. There was no significant correlation between nigrostriatal [ Conclusion: Increased striatal and frontal cortical GABAergic activity is a more significant determinant of daytime somnolence than dopaminergic functions in PD. Findings may augur novel inverse GABA

Indexed as

excessive daytime sleepinessflumazenilGABAA receptorParkinson’s diseasepositron emission tomography

Identifiers

PMID42282899
PMCPMC13251600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.