Evidence map›Paper›PMID 42282882›Full record

ArticleVideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy2026

The flushing method: a novel hemostatic technique for endoscopic submucosal dissection in insufflation and saline-immersion conditions.

Ryosuke Ishida, Takashi Toyonaga, Hiromitsu Ban, Noriko Suzuki, Douglas Motomura, Hirofumi Abe, Tetsuya Yoshizaki, Yuzo Kodama

Abstract read
In one paragraph

Article in VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryosuke IshidaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Takashi ToyonagaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Hiromitsu BanDepartment of Gastroenterology, Omi Medical Center, Kusatsu, Japan.
Noriko SuzukiWolfson Unit for Endoscopy, St Mark's Hospital, London, United Kingdom.
Douglas MotomuraDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, Canada.
Hirofumi AbeDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Tetsuya YoshizakiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Saline-immersion endoscopic submucosal dissection (ESD) offers improved visualization. It may also provide better buoyancy for the tissue to facilitate the dissection. However, achieving reliable hemostasis remains technically challenging. This article presents the "flushing method," a novel hemostatic technique enabling consistent precoagulation and bleeding control under insufflation and immersion conditions. Methods: The flushing method was developed by connecting an endoscopic irrigation pump (EIP 2; Erbe Elektromedizin GmbH, Tübingen, Germany) to a FlushKnife BT-S (Fujifilm, Tokyo, Japan) via an extension tube. Pressing the foot pedal activates both the electrosurgical unit and the irrigation pump simultaneously, ejecting saline solution from the base of the knife. This can eliminate the vaporization layer generated by high-frequency coagulation while suppressing the electrical discharge. This allows stable and safe coagulation even at higher-power settings. Results: The technique was applied during ESD for a 150-mm circumferential rectal tumor in a 55-year-old woman. A total of 129 vessels (22 branching and 107 penetrating) were precoagulated using forcedCOAG (effect 5.5) with the irrigation pump flushing. Bleeding events (n = 14) were controlled with the knife alone, without hemostatic forceps. Conclusions: The flushing method is a safe and effective technique for precoagulation and hemostasis during ESD under both insufflation and saline-immersion conditions. Its versatility may broaden the clinical applicability of ESD.

Identifiers

PMID42282882
PMCPMC13250308

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.