Evidence map›Paper›PMID 42282879›Full record

ArticleSynthetic and systems biotechnology2026

Systems engineering of

Jiaojiao Zuo, Shaolun Zhang, Wenxiao Huang, Jia Liu, Cong Gao, Gui Peng Hu, Wei Song, Xiaomin Li, Wanqing Wei, Jing Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiaojiao ZuoCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Shaolun ZhangSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Wenxiao HuangSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Jia LiuSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Cong GaoSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Gui Peng HuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Wei SongSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Xiaomin LiSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Wanqing WeiSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Jing WuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Liming LiuSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Kaifang LiuSchool of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Nan XuCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxytyrosol (HT) is a potent polyphenolic antioxidant widely utilized in the biomedical and food industries. However, its high-level microbial biosynthesis is primarily hindered by the metabolic flux imbalances and severe cellular toxicity. In this study, an artificial synthetic pathway from 4-hydroxyphenylpyruvate was constructed in an engineered l-phenylalanine producing

Indexed as

By-product eliminationCofactor engineeringFermentation optimizationHydroxytyrosolHydroxytyrosol toleranceMetabolic flux imbalances

Identifiers

PMID42282879
PMCPMC13251646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.