Evidence map›Paper›PMID 42282842›Full record

ArticlebioRxiv : the preprint server for biology2026

Yongqiang Gao, Jeremy D Amon, Joshua C Cofsky, David Z Rudner

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2026
5 · Who and what money

Authors and funding

4 authors.

Yongqiang GaoPresent address: Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Jeremy D AmonDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
Joshua C CofskyDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-0236-7143

Funding

Molecular basis of spore germinationR01AI164647 · NIAID · HARVARD MEDICAL SCHOOL · PI Andrew Kruse, DAVID Z RUDNER · 2022 to 2026
$4.2M
Identification and characterization of a comprehensive set of factors required for sporulation and germination in Bacillus anthracisR21AI171308 · NIAID · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2022 to 2023
$466k
NIAID NIH HHS R01 AI164647NIAID NIH HHS R21 AI171308
6 · The paper itself

Abstract

Bacterial endospores are encased in a thick layer of specialized peptidoglycan called the cortex that is essential for core dehydration and heat resistance. Spore germination and outgrowth requires cortex degradation by enzymes that are deposited in the spore during sporulation. How these enzymes are held inactive during dormancy and activated during germination remains poorly understood. In

Indexed as

cortex lytic enzymesgerminationM4 peptidasePepSY domainspores

Identifiers

PMID42282842
PMCPMC13252411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.