Evidence map›Paper›PMID 42282836›Full record

ArticlebioRxiv : the preprint server for biology2026

Metabolic Intervention with Dimethyl Malonate Impairs Phagocytic Clearance but Fails to Protect Neurons.

Rachel McNeel, Francisco M Nadal-Nicolás, Kirsten Overdahl, Wei Li, Alan Jarmusch, Kiyoharu J Miyagishima

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel McNeelNational Eye Institute, NIH, Bethesda, MD, USA.
Francisco M Nadal-NicolásNational Eye Institute, NIH, Bethesda, MD, USA.
Kirsten OverdahlMetabolomics Core Facility, National Institute of Environmental Health Sciences, NIH, Durahm, NC, USA.
Wei LiNational Eye Institute, NIH, Bethesda, MD, USA.
Alan JarmuschMetabolomics Core Facility, National Institute of Environmental Health Sciences, NIH, Durahm, NC, USA.
Kiyoharu J MiyagishimaNational Eye Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-9744-3152

Funding

Mass Spectrometry-based Untargeted MetabolomicsZICES103363 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JARMUSCH, ALAN · 2021 to 2025
$6.5M
Intramural NIH HHS ZIC ES103363
6 · The paper itself

Abstract

Secondary degeneration following optic nerve crush (ONC) is driven in part by mitochondrial dysfunction and microglial activation. Inspired by hibernation, where reduced succinate oxidation limits reactive oxygen species (ROS) production, we tested whether pharmacological inhibition of this pathway confers neuroprotection. Using

Indexed as

dimethyl malonate (DMM)hibernationoptic nerve crushretinasuccinate dehydrogenasethirteen-lined ground squirrel

Identifiers

PMID42282836
PMCPMC13251941

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.