Evidence map›Paper›PMID 42282827›Full record

ArticlebioRxiv : the preprint server for biology2026

A hERG Blocker Facilitates K

Steffen S Docken, Matthew J Marquis, Khoa Ngo, Yuumu Wada, Satomi Kita, Vladimir Yarov-Yarovoy, Colleen E Clancy, Igor Vorobyov, Timothy J Lewis, Kazuharu Furutani and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Steffen S DockenDepartment of Mathematics, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0003-3771-5504
Matthew J MarquisDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-5556-9072
Khoa NgoDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-7454-2924
Yuumu WadaDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Tokushima, 770-8514, Japan.
Satomi KitaDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Tokushima, 770-8514, Japan.ORCID 0000-0003-4147-6788
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-2325-4834
Colleen E ClancyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0001-6849-4885
Igor VorobyovDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-4767-5297
Timothy J LewisDepartment of Mathematics, University of California, Davis, Davis, CA 95616, USA.
Kazuharu FurutaniDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Tokushima, 770-8514, Japan.ORCID 0000-0002-9680-2205
Jon T SackDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-6975-982X

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Predictive multiscale in silico cardio-pharmacologyU01HL126273 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E · 2015 to 2019
$3.8M
Digital Twins from the Atom to the RhythmR01HL174001 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLEEN E CLANCY, Luis F Santana · 2024 to 2026
$2.4M
Metabolic Control of Cardiac PacemakingR01HL168874 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLEEN E CLANCY, Robert Harry Cudmore · 2024 to 2026
$1.9M
NHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL168874NHLBI NIH HHS R01 HL174001NHLBI NIH HHS T32 HL086350NHLBI NIH HHS U01 HL126273
6 · The paper itself

Abstract

Many drugs that block voltage-gated K

Identifiers

PMID42282827
PMCPMC13251963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.