Evidence map›Paper›PMID 42282815›Full record

ArticlebioRxiv : the preprint server for biology2026

NECAP antagonizes light-induced Rhodopsin-1 internalization to promote photoreceptor homeostasis.

Huai-Wei Huang, Michal Tyrlik, Po-Wen Huang, Adam I Yeo, Ah-Ram Kim, Norbert Perrimon, Chen-Yuan Tseng, Hugo J Bellen, Hyung Don Ryoo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huai-Wei HuangDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016.ORCID 0000-0001-8968-4952
Michal TyrlikDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Po-Wen HuangInstitute of Molecular Biology, College of Life Sciences, National Chung Hsing University, Taiwan.
Adam I YeoDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016.
Ah-Ram KimDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-9597-6759
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Chen-Yuan TsengInstitute of Molecular Biology, College of Life Sciences, National Chung Hsing University, Taiwan.ORCID 0000-0002-0383-3660
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-5992-5989
Hyung Don RyooDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-1046-535X

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Unfolded Protein Response in Eye Development and DiseaseR01EY020866 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HYUNG D RYOO · 2010 to 2026
$6.9M
A Comprehensive Resource for Manipulating the Drosophila GenomeR24OD031447 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUGO J BELLEN, Oguz Kanca · 2021 to 2026
$5.2M
NCI NIH HHS P30 CA016087NEI NIH HHS R01 EY020866NIH HHS R24 OD031447
6 · The paper itself

Abstract

AP-2 is a key mediator of clathrin-mediated endocytosis (CME) that internalizes cargo from the plasma membrane. NECAP proteins physically bind phosphorylated AP-2 during CME, but their roles during endocytosis remain unresolved, with conflicting reports about their function. Here, we report that

Indexed as

AP-2endocytosisNECAPretinal degenerationrhodopsin-1

Identifiers

PMID42282815
PMCPMC13252013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.