ArticlebioRxiv : the preprint server for biology2026
FBH1 Reverses Stalled Replication Forks via Sequential Unwinding of Nascent Strands.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Replication fork reversal is a DNA damage tolerance mechanism important for genome stability that entails annealing of parental DNA to push the fork backwards. F-box helicase 1 (FBH1) is a 3'-5' ssDNA translocase and SCF (SKP-CUL1-F box) E3 ubiquitin ligase that catalyzes fork reversal and limits aberrant recombination, yet how its helicase activity drives strand annealing is unknown. Here, using single-molecule and biochemical assays, we show that SCF
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