Evidence map›Paper›PMID 42282800›Full record

ArticlebioRxiv : the preprint server for biology2026

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism.

William Mannherz, Luke Homfeldt, Noah Lampl, Suneet Agarwal

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William MannherzDivision of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0003-4472-7394
Luke HomfeldtDivision of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital; Boston, MA, USA.
Noah LamplDivision of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital; Boston, MA, USA.
Suneet AgarwalDivision of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0003-4910-3118

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Regulation of the telomerase RNA component in hematopoiesisR01DK107716 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SUNEET AGARWAL · 2016 to 2026
$5.0M
High-Throughput DNA SequencerS10OD032203 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$804k
Control of Telomere Homeostasis by Nucleotide Metabolism in HematopoiesisF30DK135340 · NIDDK · HARVARD MEDICAL SCHOOL · PI William Mannherz · 2023 to 2026
$188k
NIDDK NIH HHS F30 DK135340NIDDK NIH HHS R01 DK107716NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIH HHS S10 OD032203
6 · The paper itself

Abstract

Genetic variation at the

Identifiers

PMID42282800
PMCPMC13252387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.