Evidence map›Paper›PMID 42282787›Full record

ArticlebioRxiv : the preprint server for biology2026

Profiling the CFTR Variant Selectivity and Off-Target Interactions of VX-121.

Ashish R Jhangiani, John A Olson, Austin Tedman, Catherine Foye, JaNise J Jackson, Ashlyn G Winters, Janiyah A White, Mia Perfetti, Grace M Abell, Crissey D Cameron and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ashish R JhangianiThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
John A OlsonDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Austin TedmanThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Catherine FoyeDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
JaNise J JacksonDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Ashlyn G WintersDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Janiyah A WhiteDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Mia PerfettiDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Grace M AbellDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Crissey D CameronDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Liudmyla ArifovaChemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA.
Brianna CormanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
J Paul RobinsonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Charles P KuntzThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Kaitlyn V LedwitchDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-3791-7392
Jens MeilerDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-8945-193X
Kathryn E OliverDepartment of Pediatrics, Emory University, Atlanta, GA, USA.ORCID 0000-0002-7781-7006
Lars PlateDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Jonathan P SchlebachThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-0955-7633

Funding

Rational optimization of combinatorial therapies for the treatment of rare cystic fibrosis variantsR01HL167046 · NHLBI · PURDUE UNIVERSITY · PI Lars Plate, Jonathan Patrick Schlebach · 2023 to 2026
$2.7M
Vanderbilt Chemical Biology Interface Training ProgramT32GM149371 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2023 to 2026
$1.7M
NHLBI NIH HHS R01 HL167046NIGMS NIH HHS T32 GM149371
6 · The paper itself

Abstract

More than 1,200 variants of the cystic fibrosis transmembrane conductance regulator gene (

Identifiers

PMID42282787
PMCPMC13252174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.