Evidence map›Paper›PMID 42282780›Full record

ArticlebioRxiv : the preprint server for biology2026

Scalable

Ivan A Kuznetsov, Kristina Li, Yijun Yang, Wencao Zhao, Wei Zhou, Wenkai Zhu, Jialiu Liang, Jian Li, Jonathan J Edwards, Zoltan Arany

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivan A KuznetsovCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.ORCID 0000-0002-2146-0538
Kristina LiCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Yijun YangCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Wencao ZhaoCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Wei ZhouCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Wenkai ZhuCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Jialiu LiangCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Jian LiCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.
Jonathan J EdwardsCardiovascular Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zoltan AranyCardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.

Funding

Selective mTORC1 inhibition to prevent and treat NAFLD and NASHR01DK107667 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ARANY, ZOLTAN P · 2016 to 2025
$5.0M
Branched chain amino acids in heart failureR01HL152446 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Zoltan P Arany · 2020 to 2026
$3.7M
Defining the Role of ROR2 in Right Ventricular Failure PathogenesisK08HL159311 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI EDWARDS, JONATHAN JOSEPH · 2021 to 2025
$657k
Computationally Driven Design of De Novo Genetically Encoded Voltage IndicatorsF30MH122076 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KUZNETSOV, IVAN · 2020 to 2023
$151k
NHLBI NIH HHS K08 HL159311NHLBI NIH HHS R01 HL152446NIDDK NIH HHS R01 DK107667NIMH NIH HHS F30 MH122076
6 · The paper itself

Abstract

Efficient identification of new targets to treat human disease requires a scalable way to link genotype to phenotype directly in the target organ. Pooled CRISPR screening with single-cell RNA sequencing as a readout (Perturb-seq) has emerged as a method for functional genomics but is typically applied

Indexed as

cardiologycardiomyopathyCRISPR screenFunctional genomicsPerturb-seq

Identifiers

PMID42282780
PMCPMC13252024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.