Evidence map›Paper›PMID 42282769›Full record

ArticlebioRxiv : the preprint server for biology2026

Mapping the vRNA Interaction with HIV-1 Integrase.

Jian Sun, Rahul Yadav, Tolga Catmakas, Luke Fisher, Nicholas C Fitzkee, Jacques J Kessl

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jian SunDepartment of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS.
Rahul YadavDepartment of Chemistry, Mississippi State University, Mississippi State, MS.
Tolga CatmakasDepartment of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS.
Luke FisherDepartment of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Mississippi State, MS.
Jacques J KesslDepartment of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS.

Funding

New Inhibitors Targeting HIV-1 Integrase During Viral MaturationR01AI140985 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Jacques J. Kessl · 2019 to 2026
$2.2M
NIAID NIH HHS R01 AI140985
6 · The paper itself

Abstract

A series of critical interactions within the viral core between the viral RNA (vRNA) and HIV-1 Integrase (IN) has previously been reported. In these studies, contact points between vRNA and IN were identified using RNA-seq and MS-based protein foot-printing approaches. Several IN amino acids located in its C-terminal domain (CTD) were found to be essential for vRNA binding and their alanine substitution severely impacted the correct morphogenesis of the matured viral core. Here, we have extended these studies by performing a comprehensive mapping of the IN-vRNA interaction by deploying RNA crosslinking and NMR methodologies. Together, these approaches were able to identify additional contacts points between the vRNA and IN. Our results reveal several new basic amino acids located in the IN CTD critical for the vRNA-IN interaction, viral replication and correct morphology of the matured viral core.

Indexed as

HIVintegrasevirus maturationvRNA

Identifiers

PMID42282769
PMCPMC13252027

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.