Evidence map›Paper›PMID 42282761›Full record

ArticlebioRxiv : the preprint server for biology2026

HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C.

Raffaele Pastore, Jack Stanley, Szilvia Kiraly, Christelle Dubois, Jlenia Monfregola, Antonio De Luca, Germano Guerra, Mark Skehel, Andrea Ballabio, Frances M Platt and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raffaele PastoreDepartment of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Via F. De Santis, 86100 Campobasso, Italy.
Jack StanleyUCL Institute of Ophthalmology, London, UK.
Szilvia KiralyUCL Institute of Ophthalmology, London, UK.
Christelle DuboisProteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Jlenia MonfregolaTelethon Institute of Genetics and Medicine (TIGEM); Naples, Italy.
Antonio De LucaDepartment of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Germano GuerraDepartment of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Via F. De Santis, 86100 Campobasso, Italy.ORCID 0000-0002-4342-962X
Mark SkehelProteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM); Naples, Italy.ORCID 0000-0003-1381-4604
Frances M PlattDepartment of Pharmacology, University of Oxford, Oxford, UK.
Emily R EdenUCL Institute of Ophthalmology, London, UK.ORCID 0000-0001-9352-5532

Funding

Dissecting and targeting lysosomal signaling in kidney tumorigenesisR01CA260205 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ANDREA BALLABIO, Roberto Zoncu · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA260205
6 · The paper itself

Abstract

Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder comprising two clinically indistinguishable but genetically distinct subtypes caused by mutations in

Identifiers

PMID42282761
PMCPMC13252130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.