Evidence map›Paper›PMID 42282746›Full record

ArticlebioRxiv : the preprint server for biology2026

Modeling in vitro cell-to-cell spread of hepatitis C viral infection using an agent-based approach.

Zhenzhen Shi, Adam Burns, Evan Cudone, Alexandra Kamm, Karina Durso-Cain, Nicholson Collier, Jonathan Ozik, Susan L Uprichard, Harel Dahari

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenzhen ShiThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.ORCID 0000-0001-9922-3957
Adam BurnsThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.ORCID 0000-0002-1630-0273
Evan CudoneThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.
Alexandra KammIntegrative Cell Biology Program, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.
Karina Durso-CainThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.
Nicholson CollierConsortium for Advanced Science and Engineering, University of Chicago, Chicago, IL.
Jonathan OzikConsortium for Advanced Science and Engineering, University of Chicago, Chicago, IL.ORCID 0000-0002-3495-6735
Susan L UprichardThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.ORCID 0000-0001-5691-1557
Harel DahariThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.ORCID 0000-0002-3357-1817

Funding

Collaborative Integration of HCV Molecular Virology and Mathematical ModelingR01AI078881 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERELSON, ALAN S, UPRICHARD, SUSAN L. · 2011 to 2025
$7.5M
NIAID NIH HHS R01 AI078881
6 · The paper itself

Abstract

Mechanisms that lead to viral chronicity are poorly understood, but cell-to-cell spread has been implicated in the establishment of chronic infections. We previously developed mathematical models to explore the nature of hepatitis C virus (HCV) cell-to-cell spread

Indexed as

agent-based modelingcell-to-cell spreadhepatitis C virus

Identifiers

PMID42282746
PMCPMC13252043

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.